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Drug-excipient compatibility studies by physico-chemical techniques - The case of indomethacin

Research Area: Uncategorized Year: 2003
Type of Publication: Article
Authors:
Journal: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY Volume: 73
Number: 2 Pages: 529-545
ISSN: 1388-6150
Note:
PhandTA 6 Symposium, MONTE VERITA, SWITZERLAND, 2002
Abstract:
This work exemplifies a general method of studying the drug-excipient interactions, with the aim of predicting rapidly and inexpensively the long term stability of their mixtures. We study the physico-chemical properties of a drug (indomethacin) in the solid state and in different combinations with several excipients (PVP=polyvinylpyrrolidone, MGST=magnesium stearate, Avicel(C)). We compare the properties of pure compounds (untreated, or moisture/temperature conditioned) with those of binary mixtures drug:excipient which underwent the same treatment. The purpose is to find indications of interactions within the mixtures, which means a potential incompatibility of the excipient. Both morphological and thermal properties are sensitive to interactions which leave mostly unmodified the IR spectra and the X-rays patterns. In particular, we find that indomethacin does interact with PVP and MGST, but is certainly compatible with Avicel(C).
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