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SYNTHESIS OF NOVEL 5 `-URIDINE-HEAD AMPHIPHILES AS MODEL FOR DNA MOLECULAR RECOGNITION

Research Area: Uncategorized Year: 2009
Type of Publication: Article
Authors:
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS Volume: 28
Number: 10 Pages: 911-923
Month: October
ISSN: 1525-7770
Abstract:
Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed. as DNA transfection agents. The Synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization. that occurs when. uridine is functionalized in this position without using protecting groups in the uracil.
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