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Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

Research Area: Uncategorized Year: 2013
Type of Publication: Article
Authors:
Journal: Bioorganic and Medicinal Chemistry Letters Volume: 23
Number: 3 Pages: 715-719
Note:
cited By (since 1996)4
Abstract:
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non peptidic PAD4 inhibitors incorporating primary/secondary guanidine moieties. © 2012 Elsevier Ltd. All rights reserved.
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