Structural and morphological study of a poly(3-hexylthiophene)/streptavidin multilayer structure serving as active layer in ultra-sensitive OFET biosensors

Research Area: Uncategorized Year: 2014
Type of Publication: Article
Journal: Journal of Physical Chemistry C Volume: 118
Number: 29 Pages: 15853-15862
cited By (since 1996)0
Organic field-effect transistors including a functional biorecognition interlayer, sandwiched between the dielectric and the organic semiconductor layers, have been recently proposed as ultrasensitive label-free biosensors capable to detect a target molecule in the low pM concentration range. The morphology and the structure of the stacked bilayer formed by the protein biointerlayer and the overlying organic semiconductor is here investigated for different protein deposition methods. X-ray scattering techniques and scanning electron microscopy allow us to gather key relevant information on the interface structure and to assess target analyte molecules capability to percolate through the semiconducting layer reaching the protein deposit lying underneath. Correlations between the structural and morphological data and the device analytical performances are established allowing us to gather relevant details on the sensing mechanism and further improving sensor performances, in particular in terms of sensitivity and selectivity. © 2014 American Chemical Society.
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