NEWS

Il Sole 24 Ore, on April 4, 2023, published an article on the IMPACTIVE Project (which involves CSGI - Unit of Cagliari) and the opportunities offered by Mechanochemical in the pharmaceutical industry (Il Sole 24 Ore)

Two researchers, Evelina Colacino (who teaches Organic Chemistry and Green Chemistry at the University of Montpellier, France) and Francesco Delogu (physical chemist, is full professor of Chemistry at the Faculty of Engineering and Architecture of the University of Cagliari, Italy) together with some European colleagues, are working to bring into the production cycle of drugs a "clean" methodology with very ancient roots, the mechanochemical. This methodology is capable of activating chemical transformations through the application of mechanical forces, which bring compression, cutting and friction. With such methods, researchers have already demonstrated that it is possible to synthesize the active substance of a drug without the use of the classic chemical reactions in which solvents are used, with a saving of energy, a reduction in polluting emissions of almost 90% and an equally significant cost reduction.

From these premises, as mentioned, the IMPACTIVE project started, involving France, Germany (with the Bam in Berlin and the Max Planck Institute in Mülheim), Italy (with the Center for Colloid and Surface Science, CSGI, Cagliari, Florence, Parma and Salerno), Holland, Belgium, Ireland, Estonia, Spain, Portugal, Switzerland and Israel. 
Evelina Colacino will lead the project and will dialogue with the different research centers and the pharmaceutical industries involved. Francesco Delogu, Coordinator of the research units of CSGI, will provide a thirty-year knowledge of the mechanisms of mechanochemistry and the instrumentation used. The attempt will be to give answers to questions still open.