Consorzio Interuniversitario per lo sviluppo dei Sistemi a Grande Interfase
Center for Colloid and Surface Science

Personal information

Position: Post-Doc


Phone: 0577-232426

Location: Siena - STCDB

Fields of Interest and Expertise

Detection of the occurrence of oxidative stress in biological samples by selecting the more suitable biomarkers and study of the intracellular and extracellular mechanisms for the antioxidant defense.

Study of the vasorelaxant properties of nitric oxide donors.

Pre-clinic study of new compounds with potential therapeutic role and evaluation of their eventual effect on physiological antioxidants.

Study on the effect of modulating the intra-and extracellular redox equilibrium for the progression of several pathological conditions.




Enzymology and Metabolic Biochemistry

Enzymology and Metabolic Biochemistry Toxicology Clinic Biochemistry

Applied Pharmacology

Curriculum Vitae

March 1996: Degree in Biological Sciences at the University of Siena, vote 110/110 cum laude. Title of the thesis: Alteration of the hematic thiolic state in rat after in vivo treatment with diamide”.

January 2001: PhD in Morphological Sciences and Lymphatology at the University of Siena, with a final thesis: “Vasodilating effect of nitrosothiols: a biochemical and morpho-functional study”.

2002-2005: Post-doctoral fellowship at the Department of Neurosciences, Pharmacology Section, University of Siena. Title of the project: “Biochemical and pharmacological analysis of nitrosothiols”.

2006: Post-doctoral fellowship at the Department of Physiopathology, Experimental Medicine and Public Health, University of Siena. Title: “Analysis of oxidative stress for the pathogenesis of pulmonary pathologies in animal models”.

2007-2009: Post-doctoral fellowship at the Department of Evolutionary Biology, University of Siena Title of the project: “Evaluation of the biological action of endogenous and exogenous nitrosothiols”.

2010: Post-doctoral fellowship at the Department of Evolutionary Biology, University of Siena. Title of the project: “Pre-clinic study of novel anti-inflammatory non steroidal drugs with reduced gastric toxicity”.

December 2010: Visiting researcher at the Department of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, Texas (USA).

2011-2012: Post-doctoral fellowship at the Department of Evolutionary Biology, University of Siena. Title of the project: “Treatment with bosentan of patients affected by systemic sclerosis: analysis of both the oxido-reductive status and the biomarkers of nitric oxide production and evaluation of the clinic efficacy of the drug”.

2013-2015: Post-doctoral fellowship in the Pharmacology Sector at the Department of Life Sciences, University of Siena. Title of the project: “Evaluation of the effect of silimarin and N-acetylcisteine in the oxido-reductive status in patients affected by diabetic nephropathy”.



NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells

- Bottoni L. - Minetti A. - Realini G. - Pio E. - Daniela Giustarini - Ranieri Rossi - Rocchio C. - Franci L. - Salvini L. - Catona O. - D’Aurizio R. - Rasa M. - Giurisato E. - Neri F. - Orlandini M. - Chiariello M. - Galvagni F.

How to Increase Cellular Glutathione

- Daniela Giustarini - Milzani A. - Dalle-Donne I. - Ranieri Rossi

Effects of Physiological and Pathological Urea Concentrations on Human Microvascular Endothelial Cells

- Colombo G. - Altomare A. - Astori E. - Landoni L. - Garavaglia M.L. - Ranieri Rossi - Daniela Giustarini - Lionetti M.C. - Gagliano N. - Milzani A. - Dalle-Donne I.
International Journal of Molecular Sciences

Effects of Nitisinone on Oxidative and Inflammatory Markers in Alkaptonuria: Results from SONIA1 and SONIA2 Studies

- Braconi D. - Geminiani M. - Psarelli E.E. - Daniela Giustarini - Marzocchi B. - Ranieri Rossi - Bernardini G. - Spiga O. - Gallagher J.A. - Le Quan Sang K.H. - Arnoux J.B. - Imrich R. - Al-Sbou M.S. - Gornall M. - Jackson R. - Ranganath L.R. - Santucci A.

Effects of the uremic toxin indoxyl sulphate on human microvascular endothelial cells

- Colombo G. - Astori E. - Landoni L. - Garavaglia M.L. - Altomare A. - Lionetti M.C. - Gagliano N. - Daniela Giustarini - Ranieri Rossi - Milzani A. - Dalle-Donne I.
Journal of Applied Toxicology

Melatonin modulates Nrf2 activity to protect porcine pre-pubertal Sertoli cells from the abnormal H2O2 generation and reductive stress effects of cadmium

- Bartolini D. - Arato I. - Mancuso F. - Daniela Giustarini - Bellucci C. - Vacca C. - Aglietti M.C. - Stabile A.M. - Ranieri Rossi - Cruciani G. - Rende M. - Calafiore R. - Luca G. - Galli F.
Journal of Pineal Research

Blood Thiol Redox State in Chronic Kidney Disease

- Garavaglia M.L. - Daniela Giustarini - Colombo G. - Reggiani F. - Finazzi S. - Calatroni M. - Landoni L. - Portinaro N.M. - Milzani A. - Badalamenti S. - Ranieri Rossi - Dalle-Donne I.
International Journal of Molecular Sciences

Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria

- Galderisi S. - Milella M.S. - Rossi M. - Cicaloni V. - Ranieri Rossi - Daniela Giustarini - Spiga O. - Tinti L. - Salvini L. - Tinti C. - Braconi D. - Millucci L. - Lupetti P. - Prischi F. - Bernardini G. - Santucci A.
Archives of Biochemistry and Biophysics

see all publications...