Position: Permanent Staff
Phone: +39 070 6758711
Organic and medicinal chemistry focused on the synthesis and development of new drug-like molecules. Liquid phase polyethylene glycol (PEG) - supported synthesis and immobilization of heterocyclic derivatives for biological and pharmaceutical technology application. Design, synthesis and in silico investigation of: - novel synthetic opioids and MOR antagonists - allosteric inhibitors of HIV-1 Reverse Transcriptase and Integrase - antitubercular agents - nematicidal and phytoactive compounds
Organic Chemistry 1
995. Single Cycle (Master) Degree in Chemistry and Pharmaceutical Technology (University of Cagliari - Summa Cum Laude) 1999. Ph.D. visiting scholar (University of Milan - Faculty of Chemistry 2000. Ph.D. in Technology and Legislation of Drugs and Bioactive Molecules (University of Cagliari) 2000 - 2002. Post Doc organic chemistry scholar (University of Cagliari - University of Milan) 2002 to present. Assistant Professor of Organic Chemistry (University of Cagliari)
2015-2016. Fulbright Research Scholar (Ohio State University)
Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor- Deventer M.H. - Persson M. - Laus A. - Pottie E. - Cannaert A. - Graziella Tocco - Gréen H. - Stove C.P.
3-[3-(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone-derived novel class of MOR-antagonists- Graziella Tocco - Laus A. - Vanejevs M. - Ture A. - Mostallino R. - Pintori N. - De Luca M.A. - Castelli M.P. - Di Chiara G.
Structural Elucidation of Relevant Gibberellic Acid Impurities and In Silico Investigation of Their Interaction with Soluble Gibberellin Receptor GID1- Pierluigi Caboni - Laus A. - Eloh K. - Ntalli N.G. - Casula M. - Di Giorgi S. - Graziella Tocco
Pharmacological characterization of novel synthetic opioids: Isotonitazene, metonitazene, and piperidylthiambutene as potent μ-opioid receptor agonists- De Luca M.A. - Graziella Tocco - Mostallino R. - Laus A. - Caria F. - Musa A. - Pintori N. - Ucha M. - Poza C. - Ambrosio E. - Di Chiara G. - Castelli M.P.
Mukaiyama reagent: An efficient reaction mediator for rapid synthesis of 1,2-disubstituted-1H-benzo[d]imidazoles- Graziella Tocco - Laus A. - Pierluigi Caboni