Consorzio Interuniversitario per lo sviluppo dei Sistemi a Grande Interfase
Center for Colloid and Surface Science

Personal information

Position: Permanent Staff


Phone: +39 070 6758711

Location: Cagliari

Fields of Interest and Expertise

Organic and medicinal chemistry focused on the synthesis and development of new drug-like molecules. Liquid phase polyethylene glycol (PEG) - supported synthesis and immobilization of heterocyclic derivatives for biological and pharmaceutical technology application. Design, synthesis and in silico investigation of: - novel synthetic opioids and MOR antagonists - allosteric inhibitors of HIV-1 Reverse Transcriptase and Integrase - antitubercular agents - nematicidal and phytoactive compounds


Organic Chemistry 1

Curriculum Vitae

995. Single Cycle (Master) Degree in Chemistry and Pharmaceutical Technology (University of Cagliari - Summa Cum Laude) 1999. Ph.D. visiting scholar (University of Milan - Faculty of Chemistry 2000. Ph.D. in Technology and Legislation of Drugs and Bioactive Molecules (University of Cagliari) 2000 - 2002. Post Doc organic chemistry scholar (University of Cagliari - University of Milan) 2002 to present. Assistant Professor of Organic Chemistry (University of Cagliari)


2015-2016. Fulbright Research Scholar (Ohio State University)



Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor

- Deventer M.H. - Persson M. - Laus A. - Pottie E. - Cannaert A. - Graziella Tocco - Gréen H. - Stove C.P.
Archives of Toxicology

3-[3-(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone-derived novel class of MOR-antagonists

- Graziella Tocco - Laus A. - Vanejevs M. - Ture A. - Mostallino R. - Pintori N. - De Luca M.A. - Castelli M.P. - Di Chiara G.
Archiv der Pharmazie

Pharmacological characterization of novel synthetic opioids: Isotonitazene, metonitazene, and piperidylthiambutene as potent μ-opioid receptor agonists

- De Luca M.A. - Graziella Tocco - Mostallino R. - Laus A. - Caria F. - Musa A. - Pintori N. - Ucha M. - Poza C. - Ambrosio E. - Di Chiara G. - Castelli M.P.

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