Position: Permanent Staff
Phone: 051 2093-671
Gene silencing in prokaryotes.
Enzymes structure and kinetics.
Overexpression and purification of proteins.
1982: Degree in Crop Sciences, at the University of Bologna (110 cum laude/110). Title: "Effect of Sowing Season on Productivity of Vicia faba".
1983-1987: PhD in Crop Sciences, at the University of Bologna. Title: "Investigations on soybean: a) inoculation of soil with Rhizobium japonicum; b) solubilization of soybean mitochondria in reverse micelles". Advisor: Prof. G. Venturi (University of Bologna); co-advisor: Prof. P.L. Luisi (Federal Institute of Technology, Zurich, Switzerland).
1987-1998: Studies and research activity at: Institute for Industrial Crops (Bologna, Italy); Institute for Plant Physiology (CNR, Milano, Italy); Federal Institute of Technology (Zurich, Switzerland); Department of Biology, University of Bologna (Bologna, Italy); Max Planck Institute for Biophysical Chemistry (Göttingen, Germany); Institut für Biologie II, University of Freiburg (Freiburg, Germany); Department of Chemistry and Biochemistry, University of Arizona (USA).
1998: fellow of the “Advanced Bacterial Genetics” course, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
1998-present: Associate Professor at the Department of Industrial Chemistry of the University of Bologna.
The Mycobacterium tuberculosis protein tyrosine phosphatase MptpA features a pH dependent activity overlapping the bacterium sensitivity to acidic conditions- Kovermann M. - Alessandra Stefan - Palazzetti C. - Immler F. - Dal Piaz F. - Bernardi L. - Cimone V. - Bellone M.L. - Alejandro Hochkoeppler
Trehalose counteracts the dissociation of tetrameric rabbit lactate dehydrogenase induced by acidic pH conditions- Simongini M. - Puglisi A. - Genovese F. - Alejandro Hochkoeppler
Amberlite XAD-4 is a convenient tool for removing Triton X-100 and Sarkosyl from protein solutions- Scutteri L. - Maltoni G. - Alejandro Hochkoeppler
High-yield production in Escherichia coli and convenient purification of a candidate vaccine against SARS-CoV-2- Maltoni G. - Scutteri L. - Mensitieri F. - Piaz F.D. - Alejandro Hochkoeppler
Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme- Iacovino L.G. - Rossi M. - Di Stefano G. - Rossi V. - Binda C. - Brigotti M. - Tomaselli F. - Pasti A.P. - Dal Piaz F. - Cerini S. - Alejandro Hochkoeppler
Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme- Pasti A.P. - Rossi V. - Di Stefano G. - Brigotti M. - Alejandro Hochkoeppler
ASFV DNA polymerase extends recessed DNAs with catalytic efficiencies outperforming those exerted on gapped DNA substrates- Lapenna A. - Alessandra Stefan - Alejandro Hochkoeppler
Production in Escherichia coli of recombinant COVID-19 spike protein fragments fused to CRM197- Bellone M.L. - Puglisi A. - Dal Piaz F. - Alejandro Hochkoeppler
Synthesis and Photochemical Properties of Manganese(I) Tricarbonyl Diimine Complexes Bound to Tetrazolato Ligands- Stout M.J. - Alessandra Stefan - Skelton B.W. - Sobolev A.N. - Massi M. - Alejandro Hochkoeppler - Stagni S. - Simpson P.V.
Substrate Activation of the Low-Molecular Weight Protein Tyrosine Phosphatase from Mycobacterium tuberculosis- Alessandra Stefan - Dal Piaz F. - Girella A. - Alejandro Hochkoeppler